Impact of sleep-disordered breathing treatment on upper airway anatomy and physiology

Highlights • Treatment reverses inflammatory, autonomic, and anatomic changes of OSA. • CPAP improves edema, increases airway volume, inflammation, and sympathetic activity. • Mandibular advancement devices increase pharyngeal area and decrease oxidative stress. • Upper airway surgical intervention...

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Veröffentlicht in:	Sleep medicine 2014-07, Vol.15 (7), p.733-741
1. Verfasser:	Shrivastava, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Apnea–hypopnea index Continuous Positive Airway Pressure Humans Mandibular Advancement Mandibular advancement device Neurology Obstructive sleep apnea Pharyngeal volume Respiratory System - pathology Respiratory System - physiopathology Reversibility of inflammation Sleep Apnea Syndromes - pathology Sleep Apnea Syndromes - physiopathology Sleep Apnea Syndromes - therapy Sleep Medicine Sleep-disordered breathing Uvulopalatopharyngoplasty Weight Loss - physiology
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Beschreibung
Zusammenfassung:	Highlights • Treatment reverses inflammatory, autonomic, and anatomic changes of OSA. • CPAP improves edema, increases airway volume, inflammation, and sympathetic activity. • Mandibular advancement devices increase pharyngeal area and decrease oxidative stress. • Upper airway surgical intervention improves pharyngeal area volume and reduces Pcrit. • Weight loss decreases nasopharyngeal collapsibility and increases pharyngeal area.
ISSN:	1389-9457 1878-5506
DOI:	10.1016/j.sleep.2014.01.002