Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination

This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.

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Veröffentlicht in:Organic & biomolecular chemistry 2014-08, Vol.12 (31), p.5856-5860
Hauptverfasser: Su, Cunxiang, Xie, Ying, Pan, Hongjie, Liu, Mao, Tian, Hua, Shi, Yian
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Biomimetics
Catalysis
Chemistry, Organic - methods
Esters - chemical synthesis
Esters - chemistry
Stereoisomerism
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Zusammenfassung:This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00684d