Molecular models for hydralazine‐related systemic lupus erythematosus

Hydralazine is the prototypic drug that induces lupus. It does so in 10-20% of patients treated on a long-term basis. Patients who are slow acetylators of hydralazine more commonly develop antinuclear antibodies and drug-related SLE. Therefore, the study of possible molecular mechanisms in hydralazi...

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Veröffentlicht in:	Arthritis and rheumatism 1981-08, Vol.24 (8), p.1082-1085
Hauptverfasser:	Dubroff, Lewis, Reid, Robert, Papalian, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antinuclear Chromatin DNA - immunology DNA - metabolism Histones - immunology Humans Hydralazine - adverse effects Lupus Erythematosus, Systemic - chemically induced Models, Molecular Models, Structural Mutagens Nucleosomes Thymidine - metabolism
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Beschreibung
Zusammenfassung:	Hydralazine is the prototypic drug that induces lupus. It does so in 10-20% of patients treated on a long-term basis. Patients who are slow acetylators of hydralazine more commonly develop antinuclear antibodies and drug-related SLE. Therefore, the study of possible molecular mechanisms in hydralazine-related SLE may be important in understanding various connective tissue diseases.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780240817