The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability

Abstract Objective We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and vulnerability (Gray-Scale median – GSM sco...

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Veröffentlicht in:	Atherosclerosis 2014-08, Vol.235 (2), p.606-612
Hauptverfasser:	Kadoglou, Nikolaos P.E, Lambadiari, Vaia, Gastounioti, Aimilia, Gkekas, Christos, Giannakopoulos, Triantafyllos G, Koulia, Katerina, Maratou, Eirini, Alepaki, Maria, Kakisis, John, Karakitsos, Petros, Nikita, Konstantina S, Dimitriadis, George, Liapis, Christos D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines C-Reactive Protein - metabolism Cardiovascular Carotid Artery Diseases - blood Carotid Artery Diseases - pathology Carotid atherosclerosis Carotid Stenosis - diagnostic imaging Carotid Stenosis - pathology Cytokines - blood GPI-Linked Proteins - blood Humans Lectins - blood Omentin-1 Plaque, Atherosclerotic - pathology Retinol-binding protein-4 Retinol-Binding Proteins, Plasma - metabolism Stroke Ultrasonography
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Zusammenfassung:	Abstract Objective We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and vulnerability (Gray-Scale median – GSM score). Methods We enrolled 225 patients with high-grade carotid stenosis (HGCS) who underwent carotid revascularization (73 Symptomatic patients, 152 asymptomatic patients) and 75 age- and sex-matched, asymptomatic individuals with low-grade (
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2014.05.957