The Effect of X Irradiation on the Capacity of Transfer RNA to Act as Substrate for Guanine-tRNA Transferase

Observation on the guanine-accepting ability of X-irradiated wheat germ tRNA shows 50% inactivation at 57,000 rad with an unusual sawtooth pattern at low doses. The sawtooth has peaks at 1330 and 3300 rad and can be modified by bovine serum albumin. RPC-5 profiles of guanylated irradiated and unirra...

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Veröffentlicht in:	Radiat. Res.; (United States) 1981-08, Vol.87 (2), p.350-359
Hauptverfasser:	Walden, Tom, Farkas, W. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	560110 - Radiation Effects on Biochemicals- (-1987) AMINES Amino acids Anticodon BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS Chromatography DNA ELECTROMAGNETIC RADIATION ENZYMES GUANINE guanine-tRNA transferase HETEROCYCLIC COMPOUNDS HYDROXY COMPOUNDS IONIZING RADIATIONS Irradiation NUCLEIC ACIDS NUCLEOTIDYLTRANSFERASES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PHOSPHORUS-GROUP TRANSFERASES PURINES Radiation damage Radiation dosage RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RNA SUBSTRATES TRANSFER RNA TRANSFERASES wheat germ X RADIATION
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Beschreibung
Zusammenfassung:	Observation on the guanine-accepting ability of X-irradiated wheat germ tRNA shows 50% inactivation at 57,000 rad with an unusual sawtooth pattern at low doses. The sawtooth has peaks at 1330 and 3300 rad and can be modified by bovine serum albumin. RPC-5 profiles of guanylated irradiated and unirradiated tRNA are identical, indicating that irradiation does not result in abnormal tRNA species, that ordinarily are not substrates for this enzyme, becoming substrates.
ISSN:	0033-7587 1938-5404
DOI:	10.2307/3575589