Methodologies for the Development of CHEST Guidelines and Expert Panel Reports

Background American College of Chest Physicians' (CHEST) new Living Guidelines Model will not only provide clinicians with guidance based on the most clinically relevant and current science but will also allow expert-informed guidance to fill in any gaps in the existing evidence. These guidance documents will be updated, as necessary, using one or more of three processes: (1) evidence-based guidelines, (2) trustworthy consensus statements, and (3) a hybrid of the other two. The new Living Guidelines Model will be more sustainable and will encourage maintenance of current and targeted recommendations and suggestions. Methods Over recent years, the Guidelines Oversight Committee (GOC), which consists of CHEST members with methodologic experience and other stakeholders, developed a rigorous process for evidence-based clinical practice guidelines. This guideline methodology will be used to the greatest extent permitted by the peer-reviewed literature. However, for some important problems clinicians seek guidance but insufficient research prevents establishing guidelines. For such cases, the GOC has created a carefully structured approach permitting a convened expert panel to develop such guidance. The foundation of this approach includes a systematic review of current literature and rigorously vetted, entrusted experts. Results Existing evidence, even if insufficient for a guideline, can be combined with a Delphi process for consensus achievement resulting in trustworthy consensus statements. This article provides a review of the CHEST methodologies for these guidance documents as well as the evidence-based guidelines. Conclusions These reliable statements of guidance for health-care providers and patients are based on a rigorous methodology and transparency of process.