Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus
The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2013-12, Vol.76 (12), p.2355-2359 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Hwang, Buyng Su Lee, Kyung Yang, Cao Jeong, Eun Ju Rho, Jung-Rae |
| description | The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells. |
| doi_str_mv | 10.1021/np400793r |
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The methylated compounds 1a and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np400793r</identifier><identifier>PMID: 24256436</identifier><language>eng</language><publisher>United States: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Alkynes - chemistry ; Alkynes - isolation & purification ; Alkynes - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Fatty Acids, Unsaturated ; Hydrocarbons, Iodinated - chemistry ; Hydrocarbons, Iodinated - isolation & purification ; Hydrocarbons, Iodinated - pharmacology ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Marine ; Marine Biology ; Mice ; Microglia - drug effects ; Molecular Structure ; Nitric Oxide - biosynthesis ; Nuclear Magnetic Resonance, Biomolecular ; Suberites ; Suberites - chemistry</subject><ispartof>Journal of natural products (Washington, D.C.), 2013-12, Vol.76 (12), p.2355-2359</ispartof><rights>Copyright © 2013 American Chemical Society and American Society of Pharmacognosy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-b1c0bd2b63debc87fffe2ebb5d95267e64ad4c726c438c46071ac46e59a032333</citedby><cites>FETCH-LOGICAL-a348t-b1c0bd2b63debc87fffe2ebb5d95267e64ad4c726c438c46071ac46e59a032333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np400793r$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np400793r$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27080,27928,27929,56742,56792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24256436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Buyng Su</creatorcontrib><creatorcontrib>Lee, Kyung</creatorcontrib><creatorcontrib>Yang, Cao</creatorcontrib><creatorcontrib>Jeong, Eun Ju</creatorcontrib><creatorcontrib>Rho, Jung-Rae</creatorcontrib><title>Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. 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Lee, Kyung ; Yang, Cao ; Jeong, Eun Ju ; Rho, Jung-Rae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-b1c0bd2b63debc87fffe2ebb5d95267e64ad4c726c438c46071ac46e59a032333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alkynes - chemistry</topic><topic>Alkynes - isolation & purification</topic><topic>Alkynes - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Fatty Acids, Unsaturated</topic><topic>Hydrocarbons, Iodinated - chemistry</topic><topic>Hydrocarbons, Iodinated - isolation & purification</topic><topic>Hydrocarbons, Iodinated - pharmacology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Marine</topic><topic>Marine Biology</topic><topic>Mice</topic><topic>Microglia - drug effects</topic><topic>Molecular Structure</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Suberites</topic><topic>Suberites - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Buyng Su</creatorcontrib><creatorcontrib>Lee, Kyung</creatorcontrib><creatorcontrib>Yang, Cao</creatorcontrib><creatorcontrib>Jeong, Eun Ju</creatorcontrib><creatorcontrib>Rho, Jung-Rae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Buyng Su</au><au>Lee, Kyung</au><au>Yang, Cao</au><au>Jeong, Eun Ju</au><au>Rho, Jung-Rae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2013-12-27</date><risdate>2013</risdate><volume>76</volume><issue>12</issue><spage>2355</spage><epage>2359</epage><pages>2355-2359</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells.</abstract><cop>United States</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>24256436</pmid><doi>10.1021/np400793r</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Alkynes - chemistry Alkynes - isolation & purification Alkynes - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Fatty Acids, Unsaturated Hydrocarbons, Iodinated - chemistry Hydrocarbons, Iodinated - isolation & purification Hydrocarbons, Iodinated - pharmacology Lipopolysaccharides - pharmacology Macrophages - drug effects Marine Marine Biology Mice Microglia - drug effects Molecular Structure Nitric Oxide - biosynthesis Nuclear Magnetic Resonance, Biomolecular Suberites Suberites - chemistry |
| title | Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus |
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