Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus

The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-12, Vol.76 (12), p.2355-2359
Hauptverfasser:	Hwang, Buyng Su, Lee, Kyung, Yang, Cao, Jeong, Eun Ju, Rho, Jung-Rae
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Alkynes - isolation & purification Alkynes - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Fatty Acids, Unsaturated Hydrocarbons, Iodinated - chemistry Hydrocarbons, Iodinated - isolation & purification Hydrocarbons, Iodinated - pharmacology Lipopolysaccharides - pharmacology Macrophages - drug effects Marine Marine Biology Mice Microglia - drug effects Molecular Structure Nitric Oxide - biosynthesis Nuclear Magnetic Resonance, Biomolecular Suberites Suberites - chemistry
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Zusammenfassung:	The previously unknown compounds 1–4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400793r