Clinical pharmacology in the development of new antidepressants: the challenges

Highlights • Deep understanding of the drug target and molecule are fundamental. • Studies in patients in Phase I may increase understanding of tolerability. • Methods to determine early signals of efficacy require further study. • A spirit of ‘hypothesis testing’ may increase Phase I success....

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Veröffentlicht in:	Current opinion in pharmacology 2014-02, Vol.14, p.6-10
Hauptverfasser:	Alexander, Robert C, Preskorn, Sheldon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Clinical Trials, Phase I as Topic - methods Depression - drug therapy Depression - physiopathology Drug Design Electroencephalography Humans Internal Medicine Magnetic Resonance Imaging - methods Medical Education Pharmacology, Clinical
Online-Zugang:	Volltext
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