Clinical pharmacology in the development of new antidepressants: the challenges

Clinical pharmacology in the development of new antidepressants: the challenges

Highlights • Deep understanding of the drug target and molecule are fundamental. • Studies in patients in Phase I may increase understanding of tolerability. • Methods to determine early signals of efficacy require further study. • A spirit of ‘hypothesis testing’ may increase Phase I success....

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Veröffentlicht in:Current opinion in pharmacology 2014-02, Vol.14, p.6-10
Hauptverfasser: Alexander, Robert C, Preskorn, Sheldon
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Clinical Trials, Phase I as Topic - methods
Depression - drug therapy
Depression - physiopathology
Drug Design
Electroencephalography
Humans
Internal Medicine
Magnetic Resonance Imaging - methods
Medical Education
Pharmacology, Clinical
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Beschreibung
Zusammenfassung:Highlights • Deep understanding of the drug target and molecule are fundamental. • Studies in patients in Phase I may increase understanding of tolerability. • Methods to determine early signals of efficacy require further study. • A spirit of ‘hypothesis testing’ may increase Phase I success.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2013.09.016