Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients

Summary Objective To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFNα/RBV). Methods A cross-sectional...

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Veröffentlicht in:	The Journal of infection 2014-02, Vol.68 (2), p.176-184
Hauptverfasser:	Guzmán-Fulgencio, María, García-Álvarez, Mónica, Berenguer, Juan, Jiménez-Sousa, Mª Ángeles, Cosín, Jaime, Pineda-Tenor, Daniel, Carrero, Ana, Aldámiz, Teresa, Álvarez, Emilio, López, Juan Carlos, Resino, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Antiviral Agents - therapeutic use Antiviral therapy Biological and medical sciences Chronic hepatitis C Cross-Sectional Studies Female General aspects Hepatic biopsy Hepatitis C virus Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - virology HIV Infections - metabolism HIV Infections - virology Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious Disease Infectious diseases Liver Cirrhosis - metabolism Liver Cirrhosis - virology Liver fibrosis Logistic Models Male Medical sciences Middle Aged Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - metabolism Vitamin D Deficiency - virology
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Zusammenfassung:	Summary Objective To study the association of plasma 25-hydroxy vitamin D (25(OH)D) levels in HIV/HCV coinfected patients with severity of liver disease and virological response to hepatitis C virus (HCV) therapy with pegylated-interferon-alpha plus ribavirin (pegIFNα/RBV). Methods A cross-sectional study in 174 HIV/HCV coinfected patients that underwent a liver biopsy previously to start HCV therapy and a retrospective study of 125 of them. Plasma 25(OH)D levels were quantified by enzyme immunoassay. Liver biopsies were evaluated by METAVIR score. A sustained virological response (SVR) was defined as an undetectable serum HCV viral load (
ISSN:	0163-4453 1532-2742
DOI:	10.1016/j.jinf.2013.10.011