Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

Highlights • Mitochondrial dysfunction substantially contributes to neurodegeneration in MS. • Neuroinflammation is the main culprit of mitochondrial alterations in MS. • Mitochondria are a putative therapeutic target in progressive MS patients.

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Veröffentlicht in:Trends in molecular medicine 2014-03, Vol.20 (3), p.179-187
Hauptverfasser: Witte, Maarten E, Mahad, Don J, Lassmann, Hans, van Horssen, Jack
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Axons - pathology
Demyelinating Diseases - pathology
Disease Models, Animal
Disease Progression
Humans
mitochondria
Mitochondria - pathology
multiple sclerosis
Multiple Sclerosis - pathology
neurodegeneration
neuroinflammation
Neurons - pathology
oxidative stress
Pathology
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Beschreibung
Zusammenfassung:Highlights • Mitochondrial dysfunction substantially contributes to neurodegeneration in MS. • Neuroinflammation is the main culprit of mitochondrial alterations in MS. • Mitochondria are a putative therapeutic target in progressive MS patients.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2013.11.007