An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

An expedient approach to pyrrolo[3,2-c]quinolines via regioselective formation of the pyrrole nucleus over indoles

An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (62), p.8526-8528
Hauptverfasser: Karkhelikar, Manjusha V, Jha, Rajeev R, Sridhar, B, Likhar, Pravin R, Verma, Akhilesh K
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Aniline Compounds - chemistry
Crystallography, X-Ray
Cyclization
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Pyrroles - chemical synthesis
Pyrroles - chemistry
Quinolines - chemical synthesis
Quinolines - chemistry
Stereoisomerism
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Zusammenfassung:An efficient approach for the synthesis of pyrrolo[3,2-c]quinolines (the core nucleus of the natural product martinellic acid) from protected 2-alkynylanilines via the regioselective formation of pyrroles followed by Heck and intramolecular Michael addition has been described.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc02466d