Role of tRNA modifications in human diseases

Highlights • Recent findings suggest a role for tRNA modifications in complex human diseases. • Implications for cancer, diabetes, neurological diseases, and mitochondrial-linked diseases. • Novel therapeutic approaches based on tRNA modifications can be devised. • There is a need to further our kno...

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Veröffentlicht in:	Trends in molecular medicine 2014-06, Vol.20 (6), p.306-314
Hauptverfasser:	Torres, Adrian Gabriel, Batlle, Eduard, Ribas de Pouplana, Lluis
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Diabetes Mellitus, Type 2 - genetics human disease Humans Mitochondrial Diseases - genetics Molecular Targeted Therapy Neoplasms - genetics Nervous System Diseases - genetics neurological disorders Pathology RNA, Transfer - chemistry RNA, Transfer - physiology tRNA tRNA modifications
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Beschreibung
Zusammenfassung:	Highlights • Recent findings suggest a role for tRNA modifications in complex human diseases. • Implications for cancer, diabetes, neurological diseases, and mitochondrial-linked diseases. • Novel therapeutic approaches based on tRNA modifications can be devised. • There is a need to further our knowledge on the dynamics of hypomodified tRNAs.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2014.01.008