Bias in chemokine receptor signalling

Bias in chemokine receptor signalling

Highlights • Variations in chemokine expression control the function of immune cells. • Biased signalling has been reported for six different chemokine receptors. • Drugs can differently affect multiple chemokines that bind to a chemokine receptor. • Biased signalling by drugs could improve pharmaco...

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Veröffentlicht in:Trends in immunology 2014-06, Vol.35 (6), p.243-252
Hauptverfasser: Zweemer, Annelien J.M, Toraskar, Jimita, Heitman, Laura H, IJzerman, Adriaan P
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Bias
biased signalling
chemokine receptors
Chemokines
Chemokines - genetics
Chemokines - metabolism
Clinical trials
Disease
Gene Expression Regulation
Humans
Immune system
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Leukocytes
Ligands
Proteins
Receptors, Chemokine - metabolism
Receptors, G-Protein-Coupled - metabolism
Rodents
Signal Transduction
Studies
Transplants & implants
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Beschreibung
Zusammenfassung:Highlights • Variations in chemokine expression control the function of immune cells. • Biased signalling has been reported for six different chemokine receptors. • Drugs can differently affect multiple chemokines that bind to a chemokine receptor. • Biased signalling by drugs could improve pharmacological profiles.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.02.004