Tetraspanin-enriched microdomains and hepatocellular carcinoma progression

Tetraspanin-enriched microdomains and hepatocellular carcinoma progression

Highlights • HCC heterogeneity may hinder personalized-medicine strategies. • HCC produces multiple subpopulations of cells with diverse genetic characteristics. • Plasma membrane protein fluctuations cause HCC phenotype multiplicity. • Tetraspanins regulate the instability of pre-malignant hepatocy...

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Veröffentlicht in:Cancer letters 2014-08, Vol.351 (1), p.23-29
Hauptverfasser: Mazzocca, Antonio, Tahmasebi Birgani, Maryam, Sabbà, Carlo, Carloni, Vinicio
Format: Artikel
Sprache:eng
Schlagworte:
Cancer heterogeneity
Cancer progression
Carcinogenesis - metabolism
Carcinogenesis - pathology
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - secondary
Cell growth
Genotype & phenotype
Hematology, Oncology and Palliative Medicine
Hepatocellular carcinoma
Humans
Lipids
Liver cancer
Liver cirrhosis
Liver diseases
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Membrane Microdomains - metabolism
Metastasis
Minor Histocompatibility Antigens
Mortality
Phosphotransferases (Alcohol Group Acceptor) - metabolism
Plasma
Proteins
Risk factors
Rodents
Tetraspanins
Tetraspanins - metabolism
Tumors
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Beschreibung
Zusammenfassung:Highlights • HCC heterogeneity may hinder personalized-medicine strategies. • HCC produces multiple subpopulations of cells with diverse genetic characteristics. • Plasma membrane protein fluctuations cause HCC phenotype multiplicity. • Tetraspanins regulate the instability of pre-malignant hepatocytes.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.05.016