Suitability of Porcine Chondrocyte Micromass Culture To Model Osteoarthritis in Vitro

In vitro tissue models are useful tools for the development of novel therapy strategies in cartilage repair and care. The limited availability of human primary tissue and high costs of animal models hamper preclinical tests of innovative substances and techniques. In this study we tested the potenti...

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Veröffentlicht in:	Molecular pharmaceutics 2014-07, Vol.11 (7), p.2092-2105
Hauptverfasser:	Schlichting, Niels, Dehne, Tilo, Mans, Karsten, Endres, Michaela, Stuhlmüller, Bruno, Sittinger, Michael, Kaps, Christian, Ringe, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage, Articular - metabolism Cell Death - genetics Cells, Cultured Chemokines - genetics Chemokines - metabolism Chondrocytes - metabolism Collagen Type II - genetics Collagen Type II - metabolism Gene Expression - genetics Gene Expression Profiling - methods Humans Osteoarthritis - genetics Osteoarthritis - metabolism Proteoglycans - genetics Proteoglycans - metabolism Swine Transcription Factors - genetics Transcription Factors - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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