The time-dependent inactivation of aromatase by 17β-hydroxy-10-methylthioestra-1,4-dien-3-one

The time-dependent inactivation of aromatase by 17β-hydroxy-10-methylthioestra-1,4-dien-3-one

17β-Hydroxy-10-methylthioestra-1,4-dien-3-one is an active-site irreversible inhibitor of aromatase, the cytochrome P-450 dependent enzyme responsible for the conversion of androst-4-ene-3,17-dione to estrone. Two time-dependent pathways to inactivation are observed, one of which requires NADPH acti...

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Veröffentlicht in:Biochemical and biophysical research communications 1981-01, Vol.103 (3), p.913-918
Hauptverfasser: Flynn, G.A., Johnston, J.O., Wright, C.L., Metcalf, B.W.
Format: Artikel
Sprache:eng
Schlagworte:
17 beta -hydroxy-10-methylthioestra-1,4-dien-3-one
aromatase
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Zusammenfassung:17β-Hydroxy-10-methylthioestra-1,4-dien-3-one is an active-site irreversible inhibitor of aromatase, the cytochrome P-450 dependent enzyme responsible for the conversion of androst-4-ene-3,17-dione to estrone. Two time-dependent pathways to inactivation are observed, one of which requires NADPH activation.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(81)90897-4