Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen

The intracellular effects of different diphosphonates on splenic macrophages were compared after intravenous injection of liposomes with encapsulated dichloromethylene diphosphonate (C12MDP), 3-amino-1-hydroxypropane-1,1-diphosphonate (APD), or 1 hydroxyethane-1,1-diphosphonate (EHDP) in similar con...

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Veröffentlicht in:	Calcified tissue international 1989-05, Vol.45 (3), p.153-156
Hauptverfasser:	VAN ROOIJEN, N, KORS, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diphosphonates - administration & dosage Diphosphonates - pharmacology Drug Carriers Etidronic Acid - pharmacology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Liposomes Macrophages - drug effects Macrophages - immunology Mice Mice, Inbred Strains Monocytes, macrophages Myeloid cells: ontogeny, maturation, markers, receptors Pamidronate Phagocytes - drug effects Spleen - cytology Spleen - drug effects
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Zusammenfassung:	The intracellular effects of different diphosphonates on splenic macrophages were compared after intravenous injection of liposomes with encapsulated dichloromethylene diphosphonate (C12MDP), 3-amino-1-hydroxypropane-1,1-diphosphonate (APD), or 1 hydroxyethane-1,1-diphosphonate (EHDP) in similar concentrations. Intracellular C12MDP was by far the most toxic compound for macrophages in the spleen. APD encapsulated in liposomes in the highest possible concentration eliminated marginal zone macrophages only and EHDP did not affect any of the macrophage subpopulations in the spleen.
ISSN:	0171-967X 1432-0827
DOI:	10.1007/bf02556058