Automated synthesis of backbone protected peptides

Automated synthesis of backbone protected peptides

The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challen...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (61), p.8316-8319
Hauptverfasser: Abdel-Aal, Abu-Baker M, Papageorgiou, George, Quibell, Martin, Offer, John
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Automation
Hemagglutinins - chemistry
Hemagglutinins - metabolism
Orthomyxoviridae - metabolism
Peptides - chemical synthesis
Peptides - chemistry
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Beschreibung
Zusammenfassung:The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03065f