Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine

Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight ( M r) 20 000–100 000 and up to 0.08% ( w v ) admixture of lipopolysaccharide was obtained by water—salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimul...

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Veröffentlicht in:	Vaccine 1989-12, Vol.7 (6), p.562-566
Hauptverfasser:	Stanislavsky, E.S., Edvabnaya, Lilie S., Bandman, Olga A., Boolk, V.F., Zhvanetskaya, M.I., Vargina, A.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial Vaccines - immunology Bacterial Vaccines - toxicity Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Guinea Pigs Immune Sera - immunology Mice Microbiology preparation of vaccines Pseudomona aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - prevention & control Rabbits Rats Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Zusammenfassung:	Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight ( M r) 20 000–100 000 and up to 0.08% ( w v ) admixture of lipopolysaccharide was obtained by water—salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimulates production of specific protective antibodies in rabbit and does not provoke obvious toxicity in laboratory animals.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/0264-410X(89)90284-3