MCF-Specific Murine Monoclonal Antibodies Made Against AKR-247 MCF Virus Recognize a Unique Determinant Associated With the gp70-p15(E) Complex

MCF-Specific Murine Monoclonal Antibodies Made Against AKR-247 MCF Virus Recognize a Unique Determinant Associated With the gp70-p15(E) Complex

Hybridomas obtained from (NFS x AKR)F sub(1) mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of vi...

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Veröffentlicht in:Journal of virology 1982-01, Vol.41 (3), p.1112-1117
Hauptverfasser: Cloyd, M W, Chesebro, B, Portis, J L, Weir, M
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container_title Journal of virology
container_volume 41
creator Cloyd, M W
Chesebro, B
Portis, J L
Weir, M
description Hybridomas obtained from (NFS x AKR)F sub(1) mice immunized with syngeneic cells infected with AKR-247 MCF virus produced antibodies specific for only AKR-247 or closely related MCF viruses which share a previously defined MCF antigen (MCFA-3). These monoclonal antibodies recognized a new type of viral antigenic determinant which appeared to be conformational determinant associated with the env) precursor polyprotein (pr80 super(env)) or its disulfide-linked gp70-p15(E) complex (gp80) but not with free gp70 or p15(E) or any other virion or virus-induced protein.
doi_str_mv 10.1128/jvi.41.3.1112-1117.1982
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title MCF-Specific Murine Monoclonal Antibodies Made Against AKR-247 MCF Virus Recognize a Unique Determinant Associated With the gp70-p15(E) Complex
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