Capillary electrophoresis technologies for screening in drug discovery

The high separation efficiency of capillary electrophoresis (CE), combined with the high selectivity and sensitivity of mass spectrometry (MS) detection offers the potential of unique resolving power and high-throughput capacity to the analysis and structural identification of complex mixtures. Recent advances in CE-MS interfaces and commercially available 96-capillary instruments have made the implementation of routine CE methods for drug screening feasible. Jeff Brockman – Psychiatric Genomics Inc., Gaithersburg, MD, USA Mark Divers – AstraZeneca, Mölndal, Sweden