Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs

The aim of this study was to investigate the effect of tunnel structured β-tricalcium phosphate (β-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution...

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Veröffentlicht in:	Dental Materials Journal 2013/03/28, Vol.32(2), pp.256-262
Hauptverfasser:	SAITO, Akira, SAITO, Emiko, KUBOKI, Yoshinori, KIMURA, Mariko, NAKAJIMA, Toshinori, YUGE, Fumihiko, KATO, Tsuyoshi, HONMA, Yoshiyuki, TAKAHASHI, Tomomi, OHATA, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - analysis Animals Basic fibroblast growth factor Beta-tricalcium phosphate Bicuspid - surgery Biocompatible Materials - therapeutic use Biomarkers - analysis Bone Substitutes - therapeutic use Bones Calcium phosphate Calcium Phosphates - therapeutic use Cementogenesis - physiology Cements Collagen Connective tissue Connective Tissue - drug effects Connective Tissue - pathology Defects Dentistry Dogs Epithelium - drug effects Epithelium - pathology Female Fibroblast Growth Factor 2 - therapeutic use Fibroblasts Furcation defects Furcation Defects - classification Furcation Defects - surgery Guided Tissue Regeneration, Periodontal - methods Isoenzymes - analysis Materials control Osteogenesis - physiology Periodontal Ligament - drug effects Random Allocation Regeneration - drug effects Root Planing - methods Root Resorption - etiology Tartrate-Resistant Acid Phosphatase Tooth Ankylosis - etiology
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Zusammenfassung:	The aim of this study was to investigate the effect of tunnel structured β-tricalcium phosphate (β-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution in conjunction with β-TCP; 2) 0.3% bFGF-2 solution; and 3) no implant material (Control group). The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. New bone formation was significantly greater in the bFGF-2/β-TCP group compared to the bFGF-2 solution and Control groups (p
ISSN:	0287-4547 1881-1361
DOI:	10.4012/dmj.2012-171