P‐Glycoprotein‐Dependent Trafficking of Nanoparticle‐Drug Conjugates

P‐glycoprotein (P‐gp) is considered to be the most prevalent and single most important cause of multidrug‐resistance (MDR) in humans. Although the protein is well known to modulate the cellular trafficking of small molecule fluorophores, antimicrobials, and up to 50% of all cytotoxic chemotherapeutics, little is known about its interactions with nanoscale drug conjugates. Here, we use P‐gp substrate‐conjugated gold nanorods as model drug carriers to investigate P‐gp‐dependent cellular trafficking of nanoparticles.