Severe Neonatal Hyperbilirubinemia and UGT1A1 Promoter Polymorphism

Severe Neonatal Hyperbilirubinemia and UGT1A1 Promoter Polymorphism

Objective To assess whether UGT1A1 promoter polymorphisms associated with Gilbert Syndrome (GS) occur with a greater frequency in neonates with severe hyperbilirubinemia. Study design In a case-control study performed at a single hospital center in Italy, 70 case subjects with severe hyperbilirubine...

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Veröffentlicht in:The Journal of pediatrics 2014-07, Vol.165 (1), p.42-45
Hauptverfasser: Travan, Laura, MD, PhD, Lega, Sara, MD, Crovella, Sergio, MD, PhD, Montico, Marcella, MSc, Panontin, Elisa, MD, Demarini, Sergio, MD
Format: Artikel
Sprache:eng
Schlagworte:
Case-Control Studies
Female
Genotype
Gilbert Disease - genetics
Glucuronosyltransferase - genetics
Humans
Hyperbilirubinemia, Neonatal - genetics
Infant, Newborn
Male
Pediatrics
Polymerase Chain Reaction
Polymorphism, Genetic
Prevalence
Promoter Regions, Genetic
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Zusammenfassung:Objective To assess whether UGT1A1 promoter polymorphisms associated with Gilbert Syndrome (GS) occur with a greater frequency in neonates with severe hyperbilirubinemia. Study design In a case-control study performed at a single hospital center in Italy, 70 case subjects with severe hyperbilirubinemia (defined as bilirubin level ≥20 mg/dL or 340 μmol/L) and 70 controls (bilirubin level
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2014.03.013