Comparison of the Efficiency of Transplantation of Bone Marrow Multipotent Mesenchymal Stromal Cells Cultured under Normoxic and Hypoxic Conditions and Their Conditioned Media on the Model of Acute Lung Injury

The therapeutic efficiency of intravenous injection of rat bone marrow multipotent mesenchymal stromal cells grown under conditions of normoxia and hypoxia (3% O 2 ) and conditioned media from these cultures were compared on the rat model of acute lung injury induced by intraperitoneal injection of...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.138-142
Hauptverfasser:	Chailakhyan, R. K., Aver’yanov, A. V., Zabozlaev, F. G., Sobolev, P. A., Sorokina, A. V., Akul’shin, D. A., Gerasimov, Yu. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - therapy Acute respiratory distress syndrome Animals Antigens, CD - metabolism Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Biology Cell Hypoxia Cells, Cultured Comparative analysis Culture Media, Conditioned - pharmacology Health aspects Hypoxia - metabolism Hypoxia - pathology Hypoxia - therapy Injections, Intraperitoneal Interleukin-1beta - biosynthesis Interleukin-1beta - secretion Interleukin-6 - biosynthesis Interleukin-6 - secretion Internal Medicine Laboratory Medicine Lipopolysaccharides Male Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Oxygen - pharmacology Pathology Rats Rats, Wistar Stem cells Transplantation Transplantation, Homologous Treatment Outcome Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - secretion
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Beschreibung
Zusammenfassung:	The therapeutic efficiency of intravenous injection of rat bone marrow multipotent mesenchymal stromal cells grown under conditions of normoxia and hypoxia (3% O 2 ) and conditioned media from these cultures were compared on the rat model of acute lung injury induced by intraperitoneal injection of lipopolysaccharide. The best therapeutic efficiency was demonstrated by cells grown under hypoxic conditions. The effect of conditioned media was less pronounced and did not depend on the culturing conditions.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2509-x