Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemic...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.103-107
Hauptverfasser:	Dubova, E. A., Pavlov, K. A., Lyapin, V. M., Kulikova, G. V., Shchyogolev, A. I., Sukhikh, G. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Female Fetus Gene Expression Humans Immunohistochemistry Infant, Newborn Infant, Small for Gestational Age Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Internal Medicine Laboratory Medicine Morphology and Pathomorphology Pathology Placenta - metabolism Placenta - pathology Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Preeclampsia Pregnancy Protein binding Proteins Severity of Illness Index Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2502-4