Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox

Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox

Methyl carbazate, a metabolite of carbadox in the rat, was administered orally to rats for 2 years. The compound was mixed in the diet at concentrations corresponding to dose levels of 0, 2.5, 5 and 10 mg/kg body wt/day. There was no evidence of any treatment-related toxicity or, in particular, of c...

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Veröffentlicht in:Toxicology (Amsterdam) 1981, Vol.22 (3), p.219-221
Hauptverfasser: Truhaut, R., Ferrando, R., Faccini, J.M., Monro, A.M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Assay
Carbadox - metabolism
Carbadox - toxicity
Carcinogens - toxicity
Female
Hydrazines - toxicity
Male
Quinoxalines - toxicity
Rats
Rats, Inbred Strains
swine
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Zusammenfassung:Methyl carbazate, a metabolite of carbadox in the rat, was administered orally to rats for 2 years. The compound was mixed in the diet at concentrations corresponding to dose levels of 0, 2.5, 5 and 10 mg/kg body wt/day. There was no evidence of any treatment-related toxicity or, in particular, of carcinogenicity.
ISSN:0300-483X
1879-3185
DOI:10.1016/0300-483X(81)90084-6