Behavioral Effects of Lead and Toxocara canis in Mice

Adult mice were administered the common parasite Toxocara canis or lead or both. The parasite clearly altered mouse performance on tests of exploration, activity, learning, and motor coordination; behavioral effects in mice receiving lead alone were less general. Consequences of Toxocara administrat...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1981-09, Vol.213 (4512), p.1142-1144
Hauptverfasser:	Dolinsky, Z. S., Burright, R. G., Donovick, P. J., Glickman, L. T., Babish, J., Summers, B., Cypess, R. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascariasis - complications Axons Behavior, Animal - physiology Boycotts Brain - parasitology Cats Children Disease Models, Animal Diseases Eggs Ganglia Helminths Host-parasite relationships Intubation Larvae Lead in the body Lead Poisoning - complications Lead Poisoning - physiopathology Male Mazes Mice Parasites Pediatric diseases Physiological aspects Toxocariasis - complications Toxocariasis - physiopathology Worms, Intestinal and parasitic
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Beschreibung
Zusammenfassung:	Adult mice were administered the common parasite Toxocara canis or lead or both. The parasite clearly altered mouse performance on tests of exploration, activity, learning, and motor coordination; behavioral effects in mice receiving lead alone were less general. Consequences of Toxocara administration appeared attenuated in animals receiving both agents. Parasite larvae were found in the central nervous system in all infected mice.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7268424