Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles

We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based “control unit”. The system consists of Janus-type nanoparticles having opposing Au and MS faces, functionalized with a pH-resp...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-06, Vol.136 (25), p.9116-9123
Hauptverfasser:	Díez, Paula, Sánchez, Alfredo, Gamella, María, Martínez-Ruíz, Paloma, Aznar, Elena, de la Torre, Cristina, Murguía, José R, Martínez-Máñez, Ramón, Villalonga, Reynaldo, Pingarrón, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Delivery Systems Enzymes, Immobilized - chemistry Enzymes, Immobilized - metabolism Esterases - chemistry Esterases - metabolism Glucose Oxidase - chemistry Glucose Oxidase - metabolism Gold - chemistry Gold - metabolism Hydrogen-Ion Concentration Kinetics Models, Molecular Molecular Structure Nanoparticles - chemistry Particle Size Porosity Silicon Dioxide - chemistry Silicon Dioxide - metabolism Surface Properties
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Beschreibung
Zusammenfassung:	We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based “control unit”. The system consists of Janus-type nanoparticles having opposing Au and MS faces, functionalized with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face. The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by the presence of d-glucose and ethyl butyrate.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja503578b