Circulating Concentrations of Soluble Receptor for AGE Are Associated With Age and AGER Gene Polymorphisms in Children With Newly Diagnosed Type 1 Diabetes

We analyzed the relationship among soluble receptor for advanced glycation end products (sRAGEs), the clinical phenotype, HLA genotype, and risk-associated single nucleotide polymorphisms (SNPs) in the AGER gene in a large population of Finnish children with newly diagnosed type 1 diabetes. Samples...

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Veröffentlicht in:	Diabetes care 2014-07, Vol.37 (7), p.1975-1981
Hauptverfasser:	SALONEN, Kirsi M, RYHÄNEN, Samppa J, FORBES, Josephine M, HÄRKÖNEN, Taina, ILONEN, Jorma, LAINE, Antti-Pekka, GROOP, Per-Henrik, KNIP, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Alleles Biological and medical sciences Case-Control Studies Child Child, Preschool Children & youth Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female General aspects Genotype Genotype & phenotype Glycation End Products, Advanced - genetics Haplotypes HLA-DR Antigens - genetics HLA-DR4 Antigen - genetics Humans Infant Male Medical diagnosis Medical sciences Metabolic diseases Phenotype Polymorphism Polymorphism, Single Nucleotide Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Risk assessment
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Zusammenfassung:	We analyzed the relationship among soluble receptor for advanced glycation end products (sRAGEs), the clinical phenotype, HLA genotype, and risk-associated single nucleotide polymorphisms (SNPs) in the AGER gene in a large population of Finnish children with newly diagnosed type 1 diabetes. Samples from 2,115 clinically phenotyped children
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc13-3049