Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes
The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3)...
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| Veröffentlicht in: | Journal of inorganic biochemistry 2014-06, Vol.135, p.54-57 |
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| container_title | Journal of inorganic biochemistry |
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| creator | Fernández, Gabriela A. Vela Gurovic, María S. Olivera, Nelda L. Chopa, Alicia B. Silbestri, Gustavo F. |
| description | The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.
The antibacterial properties of water-soluble gold(I) complexes and the respective ligands were assessed against Gram-positives and Gram-negative bacteria. The bactericidal activity displayed was comparable to that of AgNO3. [Display omitted]
•Water soluble Au(I)–NHC complexes display antibacterial effects.•The antibacterial properties are comparable to that of AgNO3.•The activity of the complexes is higher than the activity of ligands. |
| doi_str_mv | 10.1016/j.jinorgbio.2014.03.001 |
| format | Article |
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The antibacterial properties of water-soluble gold(I) complexes and the respective ligands were assessed against Gram-positives and Gram-negative bacteria. The bactericidal activity displayed was comparable to that of AgNO3. [Display omitted]
•Water soluble Au(I)–NHC complexes display antibacterial effects.•The antibacterial properties are comparable to that of AgNO3.•The activity of the complexes is higher than the activity of ligands.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2014.03.001</identifier><identifier>PMID: 24662463</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Enterococcus faecalis ; Enterococcus faecalis - drug effects ; Escherichia coli ; Escherichia coli - drug effects ; Gold - chemistry ; Heterocyclic Compounds - chemistry ; Heterocyclic Compounds - pharmacology ; Methane - analogs & derivatives ; Methane - chemistry ; Microbial Sensitivity Tests ; Micrococcus luteus ; Micrococcus luteus - drug effects ; N-heterocyclic carbene ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Solubility ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Water-soluble Au(I) ; Yersinia ruckeri ; Yersinia ruckeri - drug effects</subject><ispartof>Journal of inorganic biochemistry, 2014-06, Vol.135, p.54-57</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-1a0e3fce841f32b147ce9a4bdc4b0ae37730f1c9c8d0e003ff821dfcd84fb59b3</citedby><cites>FETCH-LOGICAL-c453t-1a0e3fce841f32b147ce9a4bdc4b0ae37730f1c9c8d0e003ff821dfcd84fb59b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinorgbio.2014.03.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24662463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández, Gabriela A.</creatorcontrib><creatorcontrib>Vela Gurovic, María S.</creatorcontrib><creatorcontrib>Olivera, Nelda L.</creatorcontrib><creatorcontrib>Chopa, Alicia B.</creatorcontrib><creatorcontrib>Silbestri, Gustavo F.</creatorcontrib><title>Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.
The antibacterial properties of water-soluble gold(I) complexes and the respective ligands were assessed against Gram-positives and Gram-negative bacteria. The bactericidal activity displayed was comparable to that of AgNO3. [Display omitted]
•Water soluble Au(I)–NHC complexes display antibacterial effects.•The antibacterial properties are comparable to that of AgNO3.•The activity of the complexes is higher than the activity of ligands.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Gold - chemistry</subject><subject>Heterocyclic Compounds - chemistry</subject><subject>Heterocyclic Compounds - pharmacology</subject><subject>Methane - analogs & derivatives</subject><subject>Methane - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Micrococcus luteus</subject><subject>Micrococcus luteus - drug effects</subject><subject>N-heterocyclic carbene</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Solubility</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Water-soluble Au(I)</subject><subject>Yersinia ruckeri</subject><subject>Yersinia ruckeri - drug effects</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFuFDEMhiNURJfCK7RzLIcZnHFmZ_a4qgpUqkBCcI4Sj9NmlZ1sk9mWvj2ptvRKD5Yl6_tt6xPiTEIjQS4_b5qNn2K6sT42LUjVADYA8o1YyKHHGlGpI7EoZFuDRHUs3ue8AYCuU_07cdyq5bIULsTP9TR7a2jm5E2odinuOM2ecxVd9WDKuM4x7G3g6iaG8fzqU_W9vuUyj_RIwVNFJlmeuKK43QX-w_mDeOtMyPzxuZ-I318uf118q69_fL26WF_XpDqca2mA0REPSjpsrVQ98cooO5KyYBj7HsFJWtEwAgOgc0MrR0fjoJztVhZPxPlhb3n6bs951lufiUMwE8d91rJT0CroUb0Clf0wIK6woP0BpRRzTuz0LvmtSY9agn5yrzf6xb1-cq8BdXFfkqfPR_Z2y-NL7p_sAqwPABcr956TzuR5Ih59Ypr1GP1_j_wF_9iagQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Fernández, Gabriela A.</creator><creator>Vela Gurovic, María S.</creator><creator>Olivera, Nelda L.</creator><creator>Chopa, Alicia B.</creator><creator>Silbestri, Gustavo F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20140601</creationdate><title>Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes</title><author>Fernández, Gabriela A. ; Vela Gurovic, María S. ; Olivera, Nelda L. ; Chopa, Alicia B. ; Silbestri, Gustavo F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-1a0e3fce841f32b147ce9a4bdc4b0ae37730f1c9c8d0e003ff821dfcd84fb59b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Enterococcus faecalis</topic><topic>Enterococcus faecalis - drug effects</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Gold - chemistry</topic><topic>Heterocyclic Compounds - chemistry</topic><topic>Heterocyclic Compounds - pharmacology</topic><topic>Methane - analogs & derivatives</topic><topic>Methane - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Micrococcus luteus</topic><topic>Micrococcus luteus - drug effects</topic><topic>N-heterocyclic carbene</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Solubility</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Water-soluble Au(I)</topic><topic>Yersinia ruckeri</topic><topic>Yersinia ruckeri - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández, Gabriela A.</creatorcontrib><creatorcontrib>Vela Gurovic, María S.</creatorcontrib><creatorcontrib>Olivera, Nelda L.</creatorcontrib><creatorcontrib>Chopa, Alicia B.</creatorcontrib><creatorcontrib>Silbestri, Gustavo F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández, Gabriela A.</au><au>Vela Gurovic, María S.</au><au>Olivera, Nelda L.</au><au>Chopa, Alicia B.</au><au>Silbestri, Gustavo F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>135</volume><spage>54</spage><epage>57</epage><pages>54-57</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3.
The antibacterial properties of water-soluble gold(I) complexes and the respective ligands were assessed against Gram-positives and Gram-negative bacteria. The bactericidal activity displayed was comparable to that of AgNO3. [Display omitted]
•Water soluble Au(I)–NHC complexes display antibacterial effects.•The antibacterial properties are comparable to that of AgNO3.•The activity of the complexes is higher than the activity of ligands.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24662463</pmid><doi>10.1016/j.jinorgbio.2014.03.001</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of inorganic biochemistry, 2014-06, Vol.135, p.54-57 |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Coordination Complexes - chemistry Coordination Complexes - pharmacology Enterococcus faecalis Enterococcus faecalis - drug effects Escherichia coli Escherichia coli - drug effects Gold - chemistry Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Methane - analogs & derivatives Methane - chemistry Microbial Sensitivity Tests Micrococcus luteus Micrococcus luteus - drug effects N-heterocyclic carbene Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Solubility Staphylococcus aureus Staphylococcus aureus - drug effects Water-soluble Au(I) Yersinia ruckeri Yersinia ruckeri - drug effects |
| title | Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes |
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