Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3)...

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Veröffentlicht in:Journal of inorganic biochemistry 2014-06, Vol.135, p.54-57
Hauptverfasser: Fernández, Gabriela A., Vela Gurovic, María S., Olivera, Nelda L., Chopa, Alicia B., Silbestri, Gustavo F.
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Sprache:eng
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Zusammenfassung:The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropylphenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coli. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. The antibacterial properties of water-soluble gold(I) complexes and the respective ligands were assessed against Gram-positives and Gram-negative bacteria. The bactericidal activity displayed was comparable to that of AgNO3. [Display omitted] •Water soluble Au(I)–NHC complexes display antibacterial effects.•The antibacterial properties are comparable to that of AgNO3.•The activity of the complexes is higher than the activity of ligands.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2014.03.001