Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus

Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded metabolites (1–8), in addition to eight previously reported compounds, two of which were isolated for the first time as free acids. Structures were established by spectroscopic methods, including HREIMS, 1H, 13C, DEPT, 1H–1H COSY, HMQC and HMBC NMR analysis. Antimicrobial activity against an array of common bacterial and fungal strains was measured via a colorimetric assay with minimal growth inhibition observed in the μg/mL range for one of the tested metabolites. •Chiliadenus montanus stems/leaves were solvent extracted.•Eight compounds in addition to eight previously reported metabolites were isolated.•Structures were established by spectroscopic methods, including MS and NMR analysis.•Antimicrobial activity against an array of common bacteria/fungi was measured.•Minimal growth inhibition for one of the known compounds was observed in the μg/mL range. Phytochemical investigations of the CH2Cl2/MeOH (1:1) extract of air-dried aerial parts of Chiliadenus montanus afforded eight metabolites, in addition to eight other previously reported compounds, of which two were isolated for the first time as free acids. Structures were established by spectroscopic methods, including HREIMS, 1H, 13C, DEPT, 1H–1H COSY, HMQC and HMBC NMR analysis. Antimicrobial activity against an array of common bacterial and fungal strains was measured via a colorimetric assay with minimal growth inhibition observed in the μg/mL range for one of the tested metabolites.