Raccoonpoxvirus safety in immunocompromised and pregnant mouse models

Highlights • Raccoonpoxvirus is much safer than vaccinia virus (WR) in Nude and SCID mice. • Raccoonpoxvirus is much safer than vaccinia virus in pregnant mice. • Addition of rabies glycoprotein does not increase virulence of raccoonpoxvirus. • Raccoonpoxvirus does not persist in mouse organs. • Rem...

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Veröffentlicht in:	Vaccine 2014-06, Vol.32 (31), p.3977-3981
Hauptverfasser:	Jones, Gwendolyn J.B, Boles, Corey, Roper, Rachel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal euthanasia Animal populations Animals Antigens, Viral - immunology Applied microbiology Biological and medical sciences Cardiovascular diseases Female Fundamental and applied biological sciences. Psychology Glycoproteins - immunology Immunocompromised Host Immunocompromised mice Immunogenicity Infections Infectious diseases Lymphocytes Mammals Mice Mice, Inbred BALB C Mice, Nude Mice, SCID Microbiology Mouse model Poxviridae Poxvirus Pregnancy Rabies virus Raccoonpox virus Rodents Safety Skin diseases Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccinia virus Viral Envelope Proteins - immunology Viral Vaccines - immunology Virulence Viruses Zoonoses
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Zusammenfassung:	Highlights • Raccoonpoxvirus is much safer than vaccinia virus (WR) in Nude and SCID mice. • Raccoonpoxvirus is much safer than vaccinia virus in pregnant mice. • Addition of rabies glycoprotein does not increase virulence of raccoonpoxvirus. • Raccoonpoxvirus does not persist in mouse organs. • Removal of thymidine kinase and hemagglutinin genes attenuates RCNV.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.05.018