Combination of HDAC inhibitor MS-275 and IL-2 increased anti-tumor effect in a melanoma model via activated cytotoxic T cells

Highlights • HDAC inhibitor, MS-275 inhibited B16 by G1 arrest, but not IL-2 in vitro. • The combination of MS-275 and IL-2 had a significant anti-tumor effect in vivo. • The anti-tumor effect was due to the increased number of activated CD8+ T cells.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2014-08, Vol.75 (2), p.140-147
Hauptverfasser:	Kato, Yukihiko, Yoshino, Ikuyo, Egusa, Chizu, Maeda, Tatsuo, Pili, Roberto, Tsuboi, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated CD8-positive T lymphocyte Administration, Oral Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Benzamides - administration & dosage Cell Proliferation - drug effects Cells, Cultured Combination therapy Dermatology Dose-Response Relationship, Drug Drug Administration Schedule Epigenesis, Genetic - drug effects Female G1 Phase Cell Cycle Checkpoints - drug effects Histone deacetylase inhibitor Histone Deacetylase Inhibitors - administration & dosage Injections, Subcutaneous Interleukin-2 Interleukin-2 - administration & dosage Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation - drug effects Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - enzymology Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice, Inbred C57BL Pyridines - administration & dosage Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology Spleen - drug effects Spleen - immunology Spleen - pathology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • HDAC inhibitor, MS-275 inhibited B16 by G1 arrest, but not IL-2 in vitro. • The combination of MS-275 and IL-2 had a significant anti-tumor effect in vivo. • The anti-tumor effect was due to the increased number of activated CD8+ T cells.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2014.04.014