Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Colloidal particles play an important role in various areas of material and pharmaceutical sciences, biotechnology, and biomedicine. In this overview we describe micro- and nano-particles used for the preparation of polyelectrolyte multilayer capsules and as drug delivery vehicles. An essential feature of polyelectrolyte multilayer capsule preparations is the ability to adsorb polymeric layers onto colloidal particles or templates followed by dissolution of these templates. The choice of the template is determined by various physico-chemical conditions: solvent needed for dissolution, porosity, aggregation tendency, as well as release of materials from capsules. Historically, the first templates were based on melamine formaldehyde, later evolving towards more elaborate materials such as silica and calcium carbonate. Their advantages and disadvantages are discussed here in comparison to non-particulate templates such as red blood cells. Further steps in this area include development of anisotropic particles, which themselves can serve as delivery carriers. We provide insights into application of particles as drug delivery carriers in comparison to microcapsules templated on them. [Display omitted] •Introduction (describes brief history and introduces the subject).•Particles and templates (this section discusses various templates used for fabrication of capsules).•Capsules (discusses which properties of capsules are affected by templates).•Complex morphologies of particles and capsules (more complicated morphologies of particles and capsules, including multicompartmental and anisotropic, are described here).•Summary (provides a brief conclusion and summary of material).