A Novel Method for Determining the Solubility of Small Molecules in Aqueous Media and Polymer Solvent Systems Using Solution Calorimetry

ABSTRACT Purpose To explore the application of solution calorimetry for measuring drug solubility in experimentally challenging situations while providing additional information on the physical properties of the solute material. Methods A semi-adiabatic solution calorimeter was used to measure the h...

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Veröffentlicht in:	Pharmaceutical research 2014-07, Vol.31 (7), p.1735-1743
Hauptverfasser:	Fadda, Hala M., Chen, Xin, Aburub, Aktham, Mishra, Dinesh, Pinal, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous chemistry Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Calorimetry - methods Chlorpropamide - chemistry Griseofulvin - chemistry Medical Law Molecules Pharmaceutical Solutions - chemistry Pharmacology/Toxicology Pharmacy Polymers Povidone - chemistry Prednisolone - chemistry Pyrrolidinones - chemistry Research Paper Ritonavir - chemistry Solubility Solution chemistry Solutions Solvents - chemistry Viscosity Water - chemistry
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Zusammenfassung:	ABSTRACT Purpose To explore the application of solution calorimetry for measuring drug solubility in experimentally challenging situations while providing additional information on the physical properties of the solute material. Methods A semi-adiabatic solution calorimeter was used to measure the heat of dissolution of prednisolone and chlorpropamide in aqueous solvents and of griseofulvin and ritonavir in viscous solutions containing polyvinylpyrrolidone and N-ethylpyrrolidone. Results Dissolution end point was clearly ascertained when heat generation stopped. The heat of solution was a linear function of dissolved mass for all drugs (
ISSN:	0724-8741 1573-904X
DOI:	10.1007/s11095-013-1278-y