Effect of once-daily tadalafil on confidence and perceived difficulty in performing sexual intercourse in men who were incomplete responders to as-needed PDE5 inhibitor treatment

Summary Introduction For men with erectile dysfunction (ED), the expectation of difficulty and level of confidence in achieving and maintaining an erection have an impact on sexual performance. Objective and methods This 12‐week, double‐blind study investigated once‐daily tadalafil (2.5 mg titrated to 5 mg or 5 mg) (n = 176) or placebo (n = 79) on confidence and perceived difficulty in performing sexual intercourse in men with ED who were incomplete responders to as‐needed phosphodiesterase‐5 inhibitor therapy. The Confidence in Performing Sexual Intercourse Questionnaire (CPSIQ) and Difficulty in Performing Sexual Intercourse Questionnaire (DPSIQ) were administered at baseline and 12 weeks. Results The mean change in CPSIQ for the tadalafil group was 1.8, which represents a shift from ‘very low’ to ‘moderate’ sexual confidence vs. a mean change of 0.5 in the placebo group (p