Methyl mercury inhibition of synaptosome protein synthesis: Role of mitochondrial dysfunction

Possible modes of organic mercurial inhibition of synaptosome protein synthesis were investigated. CH 3HgCl inhibited protein synthesis in synaptosomes harvested from both neonatal and adult rat brain cortices. Maximum inhibition occurred when incubations were performed at low synaptosome concentrat...

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Veröffentlicht in:	Environ. Res.; (United States) 1981-01, Vol.24 (2), p.286-298
Hauptverfasser:	Cheung, M., Verity, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMALS ATP BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMISTRY BIOLOGICAL EFFECTS BIOSYNTHESIS BODY BRAIN CELL CONSTITUENTS CENTRAL NERVOUS SYSTEM CHARGED PARTICLES CHEMISTRY COMPARATIVE EVALUATIONS DOSE-RESPONSE RELATIONSHIPS ENZYME ACTIVITY ENZYME INHIBITORS HYDROGEN ISOTOPES ION EXCHANGE MATERIALS IONS ISOTOPE APPLICATIONS ISOTOPES LIGHT NUCLEI MAMMALS MATERIALS METHYLMERCURY MITOCHONDRIA NEONATES NERVOUS SYSTEM NUCLEI NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC MERCURY COMPOUNDS ORGANOIDS ORGANS POTASSIUM IONS PROTEINS QUANTITY RATIO RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RATS RODENTS SENSITIVITY SODIUM IONS SYNTHESIS TRACER TECHNIQUES TRITIUM VERTEBRATES YEARS LIVING RADIOISOTOPES
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Zusammenfassung:	Possible modes of organic mercurial inhibition of synaptosome protein synthesis were investigated. CH 3HgCl inhibited protein synthesis in synaptosomes harvested from both neonatal and adult rat brain cortices. Maximum inhibition occurred when incubations were performed at low synaptosome concentrations (
ISSN:	0013-9351 1096-0953
DOI:	10.1016/0013-9351(81)90158-4