Diminution par un Dithiocarbamate Fongicide, le Zinebe, de l'Activite des Oxygenases Microsomales du Foie chez le Rat: Effects d'un Regime a 9% de Caseine

Young male rats were fed a balanced diet or one containing 9% casein. After 2 wk, each group was divided, one half being maintained as the control and the other half being fed diet containing zineb, zinc 1,2-ethylenebis(dithiocarbamate), at a level of 600 ppm (of the pure product) for 4 wk. The low-protein diet lowered the activities of aminopyrine N-demethylase (APDM) and NADPH)-cytochrome c reductase expressed in relation to protein, but increased their molecular activities per unit of P-450. The protein-deficient diet had no effect on the specific activity of aniline hydroxylase (aH) but increased the activity per unit of P-450. It also reduced the levels of cytochromes P-450 and b sub(5). Rats on this diet showed a prolonged hexobarbital-induced sleeping time. Ingestion of zineb lowered the activities of APDM and AH, calculated on the basis of protein, but had no effect on their activities expressed in terms of P)-450 units.