Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer

The human kallikrein‐related peptidase family is comprised of 15 serine protease genes on chromosome 19q13.4 . Our previous microarray analyses showed that the gene kallikrein‐related peptidase 13 (KLK13) was down‐regulated in oral squamous cell carcinoma (OSCC) cell lines. We evaluated the expressi...

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Veröffentlicht in:	Molecular carcinogenesis 2014-07, Vol.53 (7), p.557-565
Hauptverfasser:	Ishige, Shunsaku, Kasamatsu, Atsushi, Ogoshi, Kenji, Saito, Yasuhiro, Usukura, Katsuya, Yokoe, Hidetaka, Kouzu, Yukinao, Koike, Hirofumi, Sakamoto, Yosuke, Ogawara, Katsunori, Shiiba, Masashi, Tanzawa, Hideki, Uzawa, Katsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Biomarkers Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Cell Adhesion Molecules - biosynthesis Cell Line, Tumor Cell Movement - genetics Cell Proliferation Chromosomes Down-Regulation Enzymes Gene expression Humans invasiveness kallikrein-related peptidase 13 Kallikreins - biosynthesis Kallikreins - genetics Lymphatic Metastasis Metastasis migration Mouth Neoplasms - enzymology Mouth Neoplasms - pathology Neoplasm Invasiveness Oral cancer oral squamous cell carcinoma Peptides RNA Interference RNA, Small Interfering - genetics
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Zusammenfassung:	The human kallikrein‐related peptidase family is comprised of 15 serine protease genes on chromosome 19q13.4 . Our previous microarray analyses showed that the gene kallikrein‐related peptidase 13 (KLK13) was down‐regulated in oral squamous cell carcinoma (OSCC) cell lines. We evaluated the expression status of KLK13 in primary OSCCs and performed functional molecular experiments in OSCC cell lines. In 102 primary tumors studied, KLK13 expression significantly (P
ISSN:	0899-1987 1098-2744
DOI:	10.1002/mc.22007