Endoplasmic Reticulum Stress in Malignancy

The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation an...

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Veröffentlicht in:	Cancer cell 2014-05, Vol.25 (5), p.563-573
Hauptverfasser:	Clarke, Hanna J., Chambers, Joseph E., Liniker, Elizabeth, Marciniak, Stefan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - metabolism Antineoplastic Agents - therapeutic use Boronic Acids - therapeutic use Bortezomib Cell Proliferation Cell Survival eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress - physiology Endoribonucleases - metabolism Humans Neoplasms - drug therapy Neoplasms - metabolism Neovascularization, Pathologic Protein Folding Protein Serine-Threonine Kinases - metabolism Pyrazines - therapeutic use Unfolded Protein Response
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Beschreibung
Zusammenfassung:	The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccr.2014.03.015