Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage
Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic cha...
Gespeichert in:
| Veröffentlicht in: | Environmental toxicology and pharmacology 2014-05, Vol.37 (3), p.1221-1228 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1228 |
|---|---|
| container_issue | 3 |
| container_start_page | 1221 |
| container_title | Environmental toxicology and pharmacology |
| container_volume | 37 |
| creator | Ramos, A.S Correia, A.T Antunes, S.C Gonçalves, F Nunes, B |
| description | Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic changes and peroxidative damage in rainbow trout. • Alterations occurred only for high levels of exposure to acetaminophen. |
| doi_str_mv | 10.1016/j.etap.2014.04.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1536685297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1382668914000891</els_id><sourcerecordid>1536685297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-861ecdbba66a7fbe0fb2c14693647b426e080f9ee5e4ef49ba9aa72700f9fa833</originalsourceid><addsrcrecordid>eNp9UsFu1TAQjBCIlsIPcEA-ciAP20nsBKFKqJSCVKmHwtlynHWfXxM7eJOn5j_4YBxeqRCHSiuttZ4ZaWc2y14zumGUife7DUx63HDKyg1NRasn2TGrJc8llfJpehc1z4Wom6PsBeKOUlYVRf08O-JlzQST8jj7dW4tmIkES7RJcoPzYdyCJ3A3BpwjEOfJlTchbhdvtjOSYbl1iOTG9T0S7TvSuz3ED-QzTOHOWWf05IInA5it9g4HfEfSvEvTPZAOLHgDBBecYPhDHyH-868HfQMvs2dW9wiv7vtJ9uPL-fezr_nl1cW3s0-XuSkLOeW1YGC6ttVCaGlboLblhpWiKUQp25ILoDW1DUAFJdiyaXWjteSSpqHVdVGcZG8PumMMP2fASQ0ODfS99hBmVMmu5F7FG5mg_AA1MSBGsGqMbtBxUYyqNQ21U2saak1D0VS0SqQ39_pzO0D3QPlrfwJ8PAAgbbl3EBUatxrUuZhSUV1wj-uf_kc3vfMpgf4WFsBdmKNP_immkCuqrtd7WM-BlZTS1IrfIS60vg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1536685297</pqid></control><display><type>article</type><title>Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ramos, A.S ; Correia, A.T ; Antunes, S.C ; Gonçalves, F ; Nunes, B</creator><creatorcontrib>Ramos, A.S ; Correia, A.T ; Antunes, S.C ; Gonçalves, F ; Nunes, B</creatorcontrib><description>Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic changes and peroxidative damage in rainbow trout. • Alterations occurred only for high levels of exposure to acetaminophen.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2014.04.005</identifier><identifier>PMID: 24816177</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetaminophen - toxicity ; Analgesics, Non-Narcotic - toxicity ; Animals ; Biomarkers ; Catalase - metabolism ; Emergency ; Gills - drug effects ; Gills - metabolism ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Glutathione Transferase - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Malondialdehyde - metabolism ; Oncorhynchus mykiss - metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Paracetamol ; Pharmaceuticals ; Rainbow trout ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Environmental toxicology and pharmacology, 2014-05, Vol.37 (3), p.1221-1228</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-861ecdbba66a7fbe0fb2c14693647b426e080f9ee5e4ef49ba9aa72700f9fa833</citedby><cites>FETCH-LOGICAL-c437t-861ecdbba66a7fbe0fb2c14693647b426e080f9ee5e4ef49ba9aa72700f9fa833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etap.2014.04.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24816177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos, A.S</creatorcontrib><creatorcontrib>Correia, A.T</creatorcontrib><creatorcontrib>Antunes, S.C</creatorcontrib><creatorcontrib>Gonçalves, F</creatorcontrib><creatorcontrib>Nunes, B</creatorcontrib><title>Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic changes and peroxidative damage in rainbow trout. • Alterations occurred only for high levels of exposure to acetaminophen.</description><subject>Acetaminophen - toxicity</subject><subject>Analgesics, Non-Narcotic - toxicity</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Catalase - metabolism</subject><subject>Emergency</subject><subject>Gills - drug effects</subject><subject>Gills - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Malondialdehyde - metabolism</subject><subject>Oncorhynchus mykiss - metabolism</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Paracetamol</subject><subject>Pharmaceuticals</subject><subject>Rainbow trout</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsFu1TAQjBCIlsIPcEA-ciAP20nsBKFKqJSCVKmHwtlynHWfXxM7eJOn5j_4YBxeqRCHSiuttZ4ZaWc2y14zumGUife7DUx63HDKyg1NRasn2TGrJc8llfJpehc1z4Wom6PsBeKOUlYVRf08O-JlzQST8jj7dW4tmIkES7RJcoPzYdyCJ3A3BpwjEOfJlTchbhdvtjOSYbl1iOTG9T0S7TvSuz3ED-QzTOHOWWf05IInA5it9g4HfEfSvEvTPZAOLHgDBBecYPhDHyH-868HfQMvs2dW9wiv7vtJ9uPL-fezr_nl1cW3s0-XuSkLOeW1YGC6ttVCaGlboLblhpWiKUQp25ILoDW1DUAFJdiyaXWjteSSpqHVdVGcZG8PumMMP2fASQ0ODfS99hBmVMmu5F7FG5mg_AA1MSBGsGqMbtBxUYyqNQ21U2saak1D0VS0SqQ39_pzO0D3QPlrfwJ8PAAgbbl3EBUatxrUuZhSUV1wj-uf_kc3vfMpgf4WFsBdmKNP_immkCuqrtd7WM-BlZTS1IrfIS60vg</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Ramos, A.S</creator><creator>Correia, A.T</creator><creator>Antunes, S.C</creator><creator>Gonçalves, F</creator><creator>Nunes, B</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage</title><author>Ramos, A.S ; Correia, A.T ; Antunes, S.C ; Gonçalves, F ; Nunes, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-861ecdbba66a7fbe0fb2c14693647b426e080f9ee5e4ef49ba9aa72700f9fa833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetaminophen - toxicity</topic><topic>Analgesics, Non-Narcotic - toxicity</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Catalase - metabolism</topic><topic>Emergency</topic><topic>Gills - drug effects</topic><topic>Gills - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Malondialdehyde - metabolism</topic><topic>Oncorhynchus mykiss - metabolism</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Paracetamol</topic><topic>Pharmaceuticals</topic><topic>Rainbow trout</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos, A.S</creatorcontrib><creatorcontrib>Correia, A.T</creatorcontrib><creatorcontrib>Antunes, S.C</creatorcontrib><creatorcontrib>Gonçalves, F</creatorcontrib><creatorcontrib>Nunes, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos, A.S</au><au>Correia, A.T</au><au>Antunes, S.C</au><au>Gonçalves, F</au><au>Nunes, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>37</volume><issue>3</issue><spage>1221</spage><epage>1228</epage><pages>1221-1228</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic changes and peroxidative damage in rainbow trout. • Alterations occurred only for high levels of exposure to acetaminophen.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24816177</pmid><doi>10.1016/j.etap.2014.04.005</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2014-05, Vol.37 (3), p.1221-1228 |
| issn | 1382-6689 1872-7077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1536685297 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Biomarkers Catalase - metabolism Emergency Gills - drug effects Gills - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Malondialdehyde - metabolism Oncorhynchus mykiss - metabolism Oxidative stress Oxidative Stress - drug effects Paracetamol Pharmaceuticals Rainbow trout Thiobarbituric Acid Reactive Substances - metabolism |
| title | Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A40%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20acetaminophen%20exposure%20in%20Oncorhynchus%20mykiss%20gills%20and%20liver:%20Detoxification%20mechanisms,%20oxidative%20defence%20system%20and%20peroxidative%20damage&rft.jtitle=Environmental%20toxicology%20and%20pharmacology&rft.au=Ramos,%20A.S&rft.date=2014-05-01&rft.volume=37&rft.issue=3&rft.spage=1221&rft.epage=1228&rft.pages=1221-1228&rft.issn=1382-6689&rft.eissn=1872-7077&rft_id=info:doi/10.1016/j.etap.2014.04.005&rft_dat=%3Cproquest_cross%3E1536685297%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1536685297&rft_id=info:pmid/24816177&rft_els_id=S1382668914000891&rfr_iscdi=true |