Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: Detoxification mechanisms, oxidative defence system and peroxidative damage

Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic cha...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-05, Vol.37 (3), p.1221-1228
Hauptverfasser:	Ramos, A.S, Correia, A.T, Antunes, S.C, Gonçalves, F, Nunes, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Biomarkers Catalase - metabolism Emergency Gills - drug effects Gills - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Malondialdehyde - metabolism Oncorhynchus mykiss - metabolism Oxidative stress Oxidative Stress - drug effects Paracetamol Pharmaceuticals Rainbow trout Thiobarbituric Acid Reactive Substances - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Acetaminophen is widely used in human medicine, being one of the most sold drugs. • Acetaminophen can pose specific risks to aquatic biota, including oxidative stress. • Trouts exposed to acetaminophen evidenced increased oxidative stress biomarkers. • Acetaminophen caused enzymatic changes and peroxidative damage in rainbow trout. • Alterations occurred only for high levels of exposure to acetaminophen.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.04.005