Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway

Highlights • Methoxychlor (MXC) and triclosan (TCS) increased ovarian cancer cell growth. • MXC or TCS resulted in upregulation of cyclin D1 and downregulation of p21 and Bax genes. • In addition, they regulated these proteins as well in ovarian cancer cells. • MXC and TCS may stimulate ovarian canc...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-05, Vol.37 (3), p.1264-1274
Hauptverfasser:	Kim, Joo-Young, Yi, Bo-Rim, Go, Ryeo-Eun, Hwang, Kyung-A, Nam, Ki-Hoan, Choi, Kyung-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cell Cycle - drug effects Cell Cycle - physiology Cell Line, Tumor Cell Proliferation - drug effects Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Emergency Endocrine Disruptors - toxicity Endocrine-disrupting chemicals Estrogen receptors Female Gene Expression Regulation, Neoplastic - drug effects Humans Methoxychlor Methoxychlor - toxicity Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Receptors, Estrogen - metabolism Signal Transduction Triclosan Triclosan - toxicity
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Zusammenfassung:	Highlights • Methoxychlor (MXC) and triclosan (TCS) increased ovarian cancer cell growth. • MXC or TCS resulted in upregulation of cyclin D1 and downregulation of p21 and Bax genes. • In addition, they regulated these proteins as well in ovarian cancer cells. • MXC and TCS may stimulate ovarian cancer growth via an ER-dependent pathway.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.04.013