Age-related differences in kidney injury biomarkers induced by cisplatin

Highlights • Cisplatin-induced acute kidney injury was severe in young rats. • Cisplatin increased urinary excretion of KIM-1, VEGF, and TIMP-1. • Urinary protein-based biomarkers may help in early diagnosis of young patients.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2014-05, Vol.37 (3), p.1028-1039
Hauptverfasser:	Shin, Yu Jin, Kim, Tae Hyung, Won, A Jin, Jung, Ja Young, Kwack, Seung Jun, Kacew, Sam, Chung, Kyu Hyuck, Lee, Byung Mu, Kim, Hyung Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - urine Age-specific biomarkers Aging - metabolism Aging - urine Animals Antineoplastic Agents - toxicity Biomarkers - metabolism Cell Adhesion Molecules - urine Cisplatin Cisplatin - toxicity Emergency Glutathione Transferase - urine HMGB1 Protein - urine Isoenzymes - urine Kidney - drug effects Kidney - metabolism Kidney - pathology KIM-1 Male Nerve Growth Factors - urine Netrin-1 Rats, Sprague-Dawley Tumor Suppressor Proteins - urine Vascular Endothelial Growth Factor A - urine
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Beschreibung
Zusammenfassung:	Highlights • Cisplatin-induced acute kidney injury was severe in young rats. • Cisplatin increased urinary excretion of KIM-1, VEGF, and TIMP-1. • Urinary protein-based biomarkers may help in early diagnosis of young patients.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.03.014