High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain

High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain

Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurochemistry international 1989-01, Vol.15 (1), p.17-23
Hauptverfasser: Yoneda, Y, Ogita, K, Yamada, K, Kouda, T, Ohgaki, T, Uchida, S, Meguri, H
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 23
container_issue 1
container_start_page 17
container_title Neurochemistry international
container_volume 15
creator Yoneda, Y
Ogita, K
Yamada, K
Kouda, T
Ohgaki, T
Uchida, S
Meguri, H
description Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_15363443</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15363443</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_153634433</originalsourceid><addsrcrecordid>eNqNjT1uwkAQRrcgUkySO0yFoLC01vITahTkA6S3xuvFTLSedTyztLk6FuIAqb7iPb1vYQpbHQ-lrT73r2Yp8mOtPRztrjB_NfVX8Il9YJ1QKbFAuoDHOKQuR2JAVuwTk6gA8ZVaUkDv85Djw5-FDlrijrifgdKNlMKjsgbJY5jWblNv-pgVB9QwR2B-gnZC4nfzcsEo4eO5b2Z1_vo-1eU4pd8cRJuBxIcYkUPK0lQ7t3fbrXP_Fu-vQFMt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15363443</pqid></control><display><type>article</type><title>High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain</title><source>Access via ScienceDirect (Elsevier)</source><creator>Yoneda, Y ; Ogita, K ; Yamada, K ; Kouda, T ; Ohgaki, T ; Uchida, S ; Meguri, H</creator><creatorcontrib>Yoneda, Y ; Ogita, K ; Yamada, K ; Kouda, T ; Ohgaki, T ; Uchida, S ; Meguri, H</creatorcontrib><description>Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.</description><identifier>ISSN: 0197-0186</identifier><language>eng</language><ispartof>Neurochemistry international, 1989-01, Vol.15 (1), p.17-23</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Yoneda, Y</creatorcontrib><creatorcontrib>Ogita, K</creatorcontrib><creatorcontrib>Yamada, K</creatorcontrib><creatorcontrib>Kouda, T</creatorcontrib><creatorcontrib>Ohgaki, T</creatorcontrib><creatorcontrib>Uchida, S</creatorcontrib><creatorcontrib>Meguri, H</creatorcontrib><title>High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain</title><title>Neurochemistry international</title><description>Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.</description><issn>0197-0186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqNjT1uwkAQRrcgUkySO0yFoLC01vITahTkA6S3xuvFTLSedTyztLk6FuIAqb7iPb1vYQpbHQ-lrT73r2Yp8mOtPRztrjB_NfVX8Il9YJ1QKbFAuoDHOKQuR2JAVuwTk6gA8ZVaUkDv85Djw5-FDlrijrifgdKNlMKjsgbJY5jWblNv-pgVB9QwR2B-gnZC4nfzcsEo4eO5b2Z1_vo-1eU4pd8cRJuBxIcYkUPK0lQ7t3fbrXP_Fu-vQFMt</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Yoneda, Y</creator><creator>Ogita, K</creator><creator>Yamada, K</creator><creator>Kouda, T</creator><creator>Ohgaki, T</creator><creator>Uchida, S</creator><creator>Meguri, H</creator><scope>7TK</scope></search><sort><creationdate>19890101</creationdate><title>High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain</title><author>Yoneda, Y ; Ogita, K ; Yamada, K ; Kouda, T ; Ohgaki, T ; Uchida, S ; Meguri, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_153634433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoneda, Y</creatorcontrib><creatorcontrib>Ogita, K</creatorcontrib><creatorcontrib>Yamada, K</creatorcontrib><creatorcontrib>Kouda, T</creatorcontrib><creatorcontrib>Ohgaki, T</creatorcontrib><creatorcontrib>Uchida, S</creatorcontrib><creatorcontrib>Meguri, H</creatorcontrib><collection>Neurosciences Abstracts</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoneda, Y</au><au>Ogita, K</au><au>Yamada, K</au><au>Kouda, T</au><au>Ohgaki, T</au><au>Uchida, S</au><au>Meguri, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain</atitle><jtitle>Neurochemistry international</jtitle><date>1989-01-01</date><risdate>1989</risdate><volume>15</volume><issue>1</issue><spage>17</spage><epage>23</epage><pages>17-23</pages><issn>0197-0186</issn><abstract>Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0197-0186
ispartof Neurochemistry international, 1989-01, Vol.15 (1), p.17-23
issn 0197-0186
language eng
recordid cdi_proquest_miscellaneous_15363443
source Access via ScienceDirect (Elsevier)
title High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T20%3A03%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20concentrations%20of%20calmodulin%20antagonists%20inhibit%20accumulation%20and%20binding%20activities%20of%20(%20super(3)H)glutamate%20in%20rat%20brain&rft.jtitle=Neurochemistry%20international&rft.au=Yoneda,%20Y&rft.date=1989-01-01&rft.volume=15&rft.issue=1&rft.spage=17&rft.epage=23&rft.pages=17-23&rft.issn=0197-0186&rft_id=info:doi/&rft_dat=%3Cproquest%3E15363443%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15363443&rft_id=info:pmid/&rfr_iscdi=true