High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain

High concentrations of calmodulin antagonists inhibit accumulation and binding activities of ( super(3)H)glutamate in rat brain

Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfo...

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Veröffentlicht in:Neurochemistry international 1989-01, Vol.15 (1), p.17-23
Hauptverfasser: Yoneda, Y, Ogita, K, Yamada, K, Kouda, T, Ohgaki, T, Uchida, S, Meguri, H
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Sprache:eng
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Zusammenfassung:Sodium- and energy-dependent accumulation of ( super(3)H)L-glutamic acid (Glu) into rat cerebral cortical slices was inhibited by relatively high concentrations (40-100 mu M) of calmodulin antagonists, such as N-(6-aminohexyl)-1-naphthalenesulfonamide and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, in concentration-dependent and noncompetitive manners. The results suggest the possible involvement of the calmodulin system in glutamatergic neurotransmission in the brain.
ISSN:0197-0186